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Dr Greg Newson N.D.

AboutWhat Is Pyroluria?

Pyroluria is known by many different names including Pyrrole Disorder, Kryptopyrrole, Kryptopyrroluria, Pyrroluria, Pyrolle Disorder, Mauve Factor and Hemepyrrole.

Pyroluria is best described as the abnormal synthesis and metabolism of any heme producing molecule, including the oxygen-carrying molecule hemoglobin. All cells in the body produce by-products (waste) and the by-product of heme metabolism is a metabolite called hydroxyhemopyrrolin-2-one (HPL), also known as Mauve Factor. The metabolite was originally thought to be a Kryptopyrrole, but further studies have proven that this is not the case.

Pyroluria sufferers produce excessive amounts of HPL, which renders the receptors on cells unable to utilize Zinc (1-8), Vitamin B6, Biotin (9). HPL also prevents the proper manufacture of Gamma Linolenic Acid (GLA), an important Omega 6 fat.

Supplementation with these nutrients is essential to reduce the detrimental effects of elevated HPL and to reduce the severity of the signs and symptoms associated with Pyroluria.

There is some evidence that suggests Pyroluria is genetically based, especially if a parent, grandparent, aunt, uncle, brother or sister has suffered from major Depression, Bi-Polar Disorder, Alcoholism, Schizophrenia or has suicided. What we have found through treating many sufferers of Pyroluria, is that certain lifestyle factors also contribute to or exacerbate Pyroluria, and it's associated signs and symptoms. Addressing inadequate digestion, leaky gut syndrome, dysbiosis, an improper diet and stress are essential in any treatment protocol in addressing Pyroluria.

Poor diet and digestive health can lead to an increase in HPL levels (10). This makes sense as insufficient nutritional intake from a poor diet and inadequate digestion, robs the body of essential nutrients causing deficiencies. This places greater stress on the body and further inflates HPL levels.

Leaky Gut Syndrome or intestinal permeability is a condition whereby microscopic holes occur in the intestinal wall allowing undigested food, bacterial by-products, poisons and toxins to pass into the bloodstream. Leaky Gut Syndrome is commonly found in Pyroluria sufferers and further contributes to the elevation of HPL.

Studies have shown that zinc deficiency increases Leaky gut Syndrome in animal and humans (11-17).

It is a well-known fact that stress damages the intestinal wall causing intestinal inflammation, which leads to an increase in Leaky Gut Syndrome  (10, 18-20).

Dysbiosis, frequently found in Pyroluria sufferers, is an overgrowth of detrimental organisms within the intestinal tract. Dysbiosis is linked to increased HPL levels as well as a cause of Leaky Gut Syndrome (21, 22). Stress increases the adherence of bad bacteria to the intestinal wall within 30 minutes (23).

Pioneering Pyroluria researcher, Dr Carl Pfeiffer, stated on more than one occasion that stress is a major driver behind elevated HPL. Research confirms this and has shown that elevated stress levels can indeed increase the production of HPL (2,6,24). A non-published US navy study conducted in 1992 found a very rapid increase in HPL levels in male volunteers who were subjected to the stress of a brief cold-water immersion (10).

Alcohol, smoking, drugs and heavy metal exposure also increase HPL levels. This is why sufferers of Pyroluria tend to get a worsening of their symptoms 24 to 48 hours after a big night out drinking or after recreational drug use.

Video: Part 1

 

Video: Part 2


 

What Damage Does Pyroluria Metabolite HPL Cause?

HPL is classed as 'nerve poisons' (25) and as such it can cause damage to nerves, nerve cells and tissue, the brain and also interrupt messages being sent along nerve pathways especially within the brain.

Heme, a substance found in the body, has an iron atom at its core. The most commonly know heme is hemoglobin, the oxygen-carrying red pigment of the blood. Heme is not only found in the blood but in other areas including the liver and nerves. The metabolic activity of nerves is highly dependent on heme for their function, and low levels of heme leads to a metabolic crisis, resulting in neuronal or nerve cell death (26-28). The by-product of heme metabolism, Hydroxyhemopyrrolin-2-one (HPL), is believed to further decrease heme levels in humans, thus worsening the signs and symptoms associated with Pyroluria.

Animal studies showed that HPL caused a decrease in liver heme, and the heme-containing detoxification enzyme cytochrome P450, by up to 55% over a 48 hour period (29). Zinc, Vitamin B6, and Biotin are required for the production of heme and such a reduction in these nutrients results in abnormal heme levels (27,30). Heme is further depleted by stress and heavy metal exposure (27). Low levels of heme result in excess production of nitric oxide, which can cause serious damage to brain tissue and is suspected to play a role in schizophrenia, autism and Down Syndrome (31-35).

Oxidative stress or free radical damage can impair, injure and degenerate cells. Antioxidants are substances produced by the body and are found in foods that protect cells from oxidative stress, much like the way galvanised paint protects iron from rusting. The body has three major antioxidant enzymes; Glutathione, Catalase and Superoxide Dismutase and these enzymes rely on zinc or vitamin B6 in some part to assist in their production. A marginal deficiency of vitamin B6 is associated with lower levels of Glutathione production and cell mitochondrial (cell battery) decay (36-38). Catalase consists of four protein subunits, each requiring heme, and since HPL suppresses heme, we can assume that Pyroluria is associated with lower catalase levels, as is the case with schizophrenia and autism (39-41). For Pyroluria sufferers the greater the HPL, the higher the level of oxidative stress.

Pyroluria: The Statistics

The table below shows neurological and behavioral disorders along with the percentages of high HPL associated with those disorders (10).

 Diagnosed Ailment
 % of HPL
 Diagnosed Ailment
 % of HPL
       
 Acute Intermittent Porphyria
 100  Down's Syndrome
 71
 Latent Acute Intermittent Porphyria
 70  Schizophrenia Acute
 59 - 80
 Manic Depression
 47 - 50
 Schizophrenia Chronic
 40 - 50
 Depression (Non Schizophrenic)
 12 - 46
 Epilepsy  44
 Autism  46 - 48
 Learning Difficulties
40 - 47
 ADD/ADHD
 40 - 47
 Criminal Behavior
 
 Neurosis  20  - Adults With Sudden Deviance
 71
 Alcholism
 20 - 84
 - Youths, Violent Offenders
 33

The reason for the variance in some of the above figures is that it depends which study the results have come from. For example one study may have found only 20% of alcoholics had high levels of HPL whereas another study found that 84% of alcoholics had high levels of HPL.

Why Isn't Pyroluria Accepted by Mainstream Medicine?

Regrettably Pyroluria falls outside the realm of mainstream medicine because the only way to rectify the problem is by improving the sufferer's nutritional status, diet, digestion and stress levels. Thankfully there are a small group of GP's endeavoring to change this.

Mainstream medicine relies on drugs to suppress symptoms or relieve suffering. This form of treatment will not work for a person with Pyroluria and sadly these Pyroluria sufferers tend to fall through the cracks of mainstream medicine and are often misdiagnosed and given medication that does nothing to rectify the underlying problem. Unfortunately these medications can lead to a further deterioration of a person's health.

Unsure if you are suffering from Pyroluria?

We offer an easy to do Pyroluria Test Kit through Shop Pyroluria. This test can be done in the comfort of your own home, in your own time.

The Pyroluria test kit includes comprehensive instructions and a informative video on how to collect your urine sample and send it off to pathology for testing. Once we receive your Pyroluria test results we will analyse these and send you a detailed Pyroluria Treatment Plan including suggested lifestyle, dietary and nutritional recommendations. You will also be enrolled in our FREE online Pyroluria Video Treatment Series, in which Dr Greg Newson explains Pyroluria treatment, diet, digestion, stress and the underlying causes. It's that easy!

Already diagnosed with Pyroluria....unsure what to do next?

We can have variety of options available;

1) Our Adult and Child, Positive and Borderline treatment Plans offer the latest up to date treatment information and contain advice and recommendation on nutritional supplementation, diet, lifestyle issues and underlying causes.

2) Our Pyoluria Combo Packs are for adults and children diagnosed with Positive or Borderline Pyroluria and contain our recommended treatment plan and nutritional supplements. This is a more economical way of purchasing nutritional supplements for the first 4 - 8 weeks of Pyroluria treatment.

As you can see Pyroluria is a complex health issue and treatment with the relevant nutrients will help to reduce the symptoms associated with Pyroluria, but it will not address the underlying causes. Any treatment protocol for Pyroluria needs to not only support the nutritional deficiencies, but also identify and treat what has caused Pyroluria in the first place.

This article was last updated 20/02/17 by Greg Newson ND

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